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In general, Ashwagandha is thought to be safe when used in moderate amounts. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. View abstract. Varying levels of research have looked at the potential benefits of ashwagandha. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. Phytomedicine 2000;7(6):463-469. Some people may need to avoid taking Ashwagandha, however, including those who: 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. Can Ashwagandha and SSRI be taken together? - iCliniq Ashwagandha might cause sleepiness and slowed breathing. The liver damage never progressed to liver failure, and most cases were resolved within five months. View abstract. Durg S, Bavage S, Shivaram SB. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. Phytotherapy Research 1991;5:111-114. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. The Incredible Benefits of Ashwagandha Leaves for Weight Loss Some but not all ashwagandha supplements are organic. Researchers from a different study believe that withanone (Win), a bioactive substance found in ashwagandha, is to blame for the liver damage. J Clin Lab Anal 2008;22:295-301. 2020. View abstract. This information does not contain all possible interactions or adverse effects. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. 2020;10(11):e01760. Acta Oncol. View abstract. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. J Ethnopharmacol. However, some adverse effects are generally associated with ashwagandha. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Supplements That Are Similar to Ashwagandha. View abstract. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Holistic Medicine 42 years experience. Ashwagandha Blood Pressure Medication Interaction Levothyroxine is used to treat the following conditions: Hashimoto's disease. 2019;11(12):e6466. If you are experiencing serious medical symptoms, please see the Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Ashwagandha interacts with 623 drugs. All rights reserved. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Ultimately, the supplements and foods you can . Diarrhea. Does Ashwagandha Interact With Any Medications? Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Take extra care if you are using drugs to help you relax or sleep. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Benefits of Ashwagandha and How Much To Take - Cleveland Clinic Ashwagandha - Benefits | Side-Effects | Safety Concerns | Interactions View abstract. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. hydrochlorothiazide, spironolactone, chlorthalidone). As an adaptogen, helping the body resist physiological and psychological stress, Steroidal lactones (withanolides, withaferins), GLP-1 Agonists (e.g. Taking high doses of ashwagandha may increase your risk of side effects. Ashwagandha may interact with certain drugs by enhancing or negating their actions. Ashwagandha: Supplement, Uses, Side Effects, Dosages, Interactions View abstract. Cureus. Antioxidants (Basel). View abstract. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. However, the review noted various limitations of the studies, including study design and potential bias. WebMD does not provide medical advice, diagnosis or treatment. Indian J Physiol Pharmacol. 2012;10(1):48-49. View abstract. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. Herbs like Ashwagandha are known to interact with SSRI and other medicines. Can You Take A Z-Pak If You Have A Penicillin Allergy? The combination could result in excess thyroid hormone in the body, which has many negative effects. This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. Ashwagandha supplements come in various forms, including capsules, gummies, caplets, liquid extracts, and powders. Ashwagandha And Lexapro (An Overview) | OptimistMinds Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Indian J Psychol Med. Most ashwagandha supplements are naturally vegan and gluten-free. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Are there any side effects of ashwagandha? Withania somnifera extract. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Cureus 2022;14(10):e30433. Read More. J Ayurveda Integr Med. J Pharm Pharmacol 1998;50:1065-68. I was told that I had an allergic reaction to penicillin when I was a child. In large amounts, any of these could potentially affect the way your body processes antidepressants. 4. Usually ashwagandha is taken 1000 mg per day, for the course of 3 to 4 months. This product can contain high amounts of iron. Ashwagandha may lower blood sugar (i.e. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. Phytother Res 2022. 2022 Mar 25;14(3):e23494. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. National Library of Medicines list Front Pharmacol 2022;13:901710. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. All rights reserved. 9-1-2010;10(3):238-246. Talk with a healthcare provider about which herb or supplement may be best for you. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Indian J Exp Biol. View abstract. Long-term safety studies on ashwagandha are lacking. 1998;60(2):173-178. The specific components of physical performance included strength and power, endurance, and fatigue/recovery. Be sure to tell your doctor if you are breastfeeding. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Ghosal S, Lal J, Srivastava R, and et al. View abstract. Does Ashwagandha Interact With Any Medications? View abstract. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. View abstract. Ashwagandha - More Interactions. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. What are some herbs that are contraindicated with Cotellic (cobimetinib)? You will need to talk about the benefits and risks of using this natural product. These include drugs like thyroid desiccated, levothyroxine, or liotrix. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. As with many other herbal supplements, little research is available on possible interactions. View abstract. View abstract. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. Therapeutic Research Faculty 2020. Evid Based Complement Alternat Med. This is according to a recent review of case studies of liver damage caused by ashwagandha. ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check If possible, choose an ashwagandha supplement that has been reviewed and approved by a third-party agency, like USP, NSF International, or ConsumerLab. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. Select a condition to view a list of vitamins. Cureus 2022;14(10):e30787. O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. J Ethnopharmacol. Underactive Thyroid. View abstract. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. Information from this source is evidence-based and objective, and without commercial influence. Typically, ashwagandha does not need to be refrigerated, but you should follow any storage directions provided by the supplement brand. View abstract. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Some barbiturates include phenobarbital, pentobarbital and secobarbital. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. Is Fish Oil Dangerous With Antidepressants? You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Can I Take Lexapro & Vitamin Supplements? J Clin Med 2021;10(16):3644. Acta Pol.Pharm. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. Ashwagandha drug interactions | HealthTap Online Doctor Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. View abstract. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Drugs that cause sleepiness and drowsiness are called sedatives. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. The roots can be used topically as a poult. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. losartan, valsartan, telmisartan), Beta-Blockers (e.g. It may cause you to become sleepy or drowsy. Answered by Dr. Brian Staiger, PharmD Available for Android and iOS devices. View abstract. Indian J Med Res 2015 Jan;141(1):100-6. Xanax. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. I am wondering if it is okay to take with my prescriptions. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. View abstract. View abstract. According to their lab study, withanone may interfere with DNA, leading to liver damage. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Large-scale studies are necessary to prove ashwagandha's effects on stress further. Fortunately, no cases resulted in liver failure, and all recovered. of signs you need emergency medical attention or call 911. Some ontologies are recognized by everyone, diabetes insipidus medication side effects and some are recognized noni lower blood sugar as ontologies only by . Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. View abstract. Medical Content Reviewed By HelloPharmacist When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. Ashwagandha is native to India and Southeast Asia and is one of the most important herbs in Ayurveda, an alternative natural system of medicine that originated in Indian over 3,000 years ago. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. View abstract. Be sure to confirm new supplements fit your dietary needs or preferences. Consult your doctor before taking ashwagandha if you use digoxin. J Clin Psychiatry. PLoS One 2009;4:e6628. 2019;98(37):e17186. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo.