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Examples of these side effects include: Also, Ofev can sometimes cause liver problems. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you drink alcohol, talk with your doctor about how much (if any) is safe to drink while taking Ofev. Its available in two strengths: 100 milligrams (mg) and 150 mg. For information about the effectiveness of Ofev, see the Ofev uses section below. Nintedanib: MedlinePlus Drug Information Nintedanib (Oral Route) Description and Brand Names - Mayo Clinic Brand name: Ofev It can also interact with certain supplements. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Early diagnosis and proper care are critical to helping people treat their condition. Ofev is not a cure for IPF or ILD, but this medicine can slow the effects of these diseases on your lungs. Be sure to tell your doctor how you are feeling during your treatment. In 2017, Boehringer Ingelheim achieved net sales of about $20.4 billion (18.1 billion euros). Thats because these lung conditions stop your body getting enough oxygen. Immunosuppressants are drugs that weaken your immune system. We comply with the HONcode standard for trustworthy health information. Your doses should be taken about 12 hours apart with food. to slow the rate of decline in lung function in adults with systemic sclerosis-associated interstitial lung disease (SSc-ILD) (also known as scleroderma-associated ILD). Actemra, Ofev, tocilizumab, pirfenidone, Esbriet, Actimmune, interferon gamma-1b. Unless your doctor tells you otherwise, continue your normal diet. Eur Respir J 2015; 46: 795806. Nintedanib is also used to slow the rate of decline in lung function in people with systemic sclerosis-associated interstitial lung disease (SSc-ILD; also known as scleroderma-associated ILD: a disease in which there is scarring of the lungs that is often fatal). The scarring in your lungs tends to get worse over time. While the availability of two agents for a progressive and fatal disease is welcomed, questions remain regarding indications and timing of initiation, side effects, and long-term outcomes. Gastrointestinal events, mainly diarrhoea, are the main adverse events caused by the treatment. The Food and Drug Administration (FDA) approves prescription drugs such as Ofev to treat certain conditions. IPF causes scar tissue to form deep within your lungs. It is also used to treat certain types of chronic fibrosing interstitial lung diseases (ILD; an ongoing disease in which there is increased scarring of the lungs). Decreased lung function can make it hard for you to breathe. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Women who are able to become pregnant should use highly effective birth control at the start of treatment, during treatment, and for at least 3 months after treatment. Cho HJ, Hwang JA, Yang EJ, Kim EC, Kim JR, Kim SY, Kim YZ, Park SC, Lee YS. We comply with the HONcode standard for trustworthy health information. If you have any of these problems, talk with your doctor about which highly effective birth control method is right for you. Ofevs manufacturer doesnt give birth control recommendations for males* taking Ofev. Treatment can help relieve, A bronchoscopy is a safe, relatively quick procedure. Boehringer Ingelheim is one of the world's top 20 pharmaceutical companies. Your doctor might prescribe an immunosuppressant if your lung condition is caused by an autoimmune condition. If you think you or someone else may have overdosed on: Ofev (Nintedanib) , call your doctor or the Poison Control center (800) 222-1222 You should always consult your doctor or another healthcare professional before taking any medication. Its not known if Ofev passes into breast milk. Generic name: nintedanib [nin-TED-a-nib] If you have a question that is not answered, call our free Lung HelpLine at 1-800-LUNGUSA (1-800-586-4872). The usual recommended dosage of nintedanib is a 150 mg capsule swallowed whole with liquid, taken twice daily approximately 12 hours apart. As a result, your organs and other body tissues may not get enough oxygen. Talk with your doctor about using a form of birth control that isnt affected by vomiting or diarrhea, such as an injection or implant. are a smoker. Can diet help improve depression symptoms? If youre not sure if youll need prior authorization for Ofev, contact your insurance company. If youre pregnant or plan to become pregnant, talk with your doctor about alternative treatment options for your lung condition. If its not managed, this can lead to dehydration (low level of fluid in your body). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Women should not become pregnant while taking nintedanib. Drug class: Multikinase inhibitors. See Important information section above. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This could increase your risk for side effects from Ofev. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Some supplements may help with the symptoms of lung disease. This article provides several useful tips on medication disposal. It is also used to treat people with a chronic (long-lasting) interstitial lung disease in which lung fibrosis continues to progress or becomes worse. Serious side effects from Ofev arent common, but they can occur. Get emergency medical help if you have signs of an allergic reaction to Ofev: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Ofev (nintedanib) for Lung Disease: Side Effects & Dosage - MedicineNet Information is also available online at https://www.poisonhelp.org/help. Nintedanib is a drug that has been approved by the FDA for some types of Interstitial lung disease (ILD) which have symptoms of shortness of breath, a dry cough, feeling tired and chest discomfort. Non-receptor tyrosine kinases: Lck, Lyn, and Src kinases. Keep a list of the medicines you take and show it to your doctor and pharmacist when you get a new medicine. TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: The most common side effects of Ofev are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure. If you miss a dose of this medicine, take your next dose at your regular time. Take with food and a full glass of water. Pirfenidone Uses, Side Effects & Warnings - Drugs.com FVC (forced vital capacity) is a lung function test that measures the total amount of air exhaled during the forced expiratory volume (FEV) test. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. Yu R, Gao D, Bao J, Sun R, Cui M, Mao Y, Li K, Hu E, Zhai Y, Liu Y, Gao Y, Xiao T, Zhou H, Yang C, Xu J. Int J Mol Sci. Ofev isnt known to interact with alcohol. With idiopathic pulmonary fibrosis, scar tissue builds up in the interstitium in your lungs. Interstitial lung disease makes breathing difficult. Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Copyright 1996-2023 Cerner Multum, Inc. Interstitial lung disease makes breathing difficult and causes shortness of breath and fatigue. Some people may also have acute flare-ups, where symptoms suddenly and unexpectedly get worse. Nintedanib Market Recent Developments and Updates By 2030 No, Ofev doesnt reverse existing scarring in your lungs. In clinical trials, fatigue was common with Ofev. Study Shows OFEV (nintedanib) Slows Progression of IPF | BI US Continue reading. If youre interested in this option, check with your doctor, pharmacist, or insurance company. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while taking Ofev. Ofev is FDA-approved to treat chronic (long-term) interstitial lung disease with worsening fibrosis (scarring) in adults. If you are pregnant or planning a pregnancy: If you are breastfeeding or are planning to breastfeed: Ofev Inactive ingredients: Medically reviewed by Judith Stewart, BPharm. . Take your doses at regular intervals, usually every 12 hours. Do not take more Ofev than your doctor recommends. Drugs R D. 2018 Mar;18(1):19-25. doi: 10.1007/s40268-017-0221-9. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Some may be a better fit for you than others. Your nintedanib will be delivered to your house by a company called Polar Speed. Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review. However, be sure to take the dosage your doctor prescribes for you. Serious Side Effects TELL YOUR DOCTOR RIGHT AWAY if you are experiencing any side effects, including: + Open All Liver Problems Diarrhea Nausea and Vomiting Heart Attack Stroke You should not breastfeed while taking nintedanib. The average age of the patients was 66.9 years in the Ofev 150 mg twice daily group and 66.6 years in the placebo group. Epub 2018 Jan 12. Talk to your doctor about birth control methods that you can use during your treatment and for at least 3 months after your last dose of nintedanib. Continue reading, Experts are not sure exactly why Ofev causes diarrhea but research has suggested that it may be due to receptor inhibition (Ofev is a triple receptor [PDGFR, VEGFR, or FGFR] tyrosine kinase inhibitor) or via a direct inflammatory action on intestinal mucosa by Ofev or its breakdown products. One in the morning and 1 in the evening, about 12 hours apart. About the Disease Disease Progression This tells your doctor the effect your lung disease has on your ability to inhale and exhale, and this measurement, alongside others such as worsening symptoms or worsening imaging, determine how effective nintedanib is for you at slowing disease progression.